The striker believes the Rossoneri are dependant on one man and says his side can claim the points if they replicate their performance against Barcelona
Bojan spent last season on loan with the Rossoneri and played alongside the Italy international following his January move to San Siro, before leaving for the Eredivisie giants on another season-long loan from Barcelona over the summer.
And when asked to assess the credentials of the Amsterdam club's latest European opponents, Bojan highlighted Balotelli as Milan's primary threat.
"It will be an important game and Milan have great players," the 23-year-old Spaniard told SkySport24.
"But Balotelli is the main danger, he creates about 80% of the opportunities for the team."
Bojan will miss the game through injury but insists Frank de Boer's side can claim a win as long as they take the positives from their opening game drubbing against his parent club.
"We know it will be tough but if we play like we know we can, then we can pick up the points.
"We'll have to press hard, push up and play with the ball as we did against Barca."