With qualification to the knockout stages already secured, Sir Alex Ferguson has left out the likes of Ryan Giggs, Paul Scholes, David De Gea and Antonio Valencia
United have already secured their place in the knockout stages of the competition, as a 3-1 win in Braga almost a fortnight ago made it four wins out of four so far.
And with his team looking to maintain their Premier League title challenge, Ferguson has opted to rest a number of senior names - including Paul Scholes, Ryan Giggs, Antonio Valencia and David De Gea - in favour of some of the club's younger players.
Goalkeeper Sam Johnstone and defender Tom Thorpe are both yet to make a senior appearance for the Old Trafford side, have featured at Under-21 level for the club and are capped at England Under-19 level.
Manchester United squad in full:
Goalkeepers: Sam Johnstone, Anders Lindegaard.
Defenders: Rafael, Alexander Buttner, Phil Jones, Tom Thorpe, Marnick Vermijl, Scott Wootton.
Midfielders: Michael Carrick, Davide Petrucci, Larnell Cole, Tom Cleverley, Darren Fletcher, Anderson, Nick Powell, Ashley Young, Ryan Tunnicliffe.
Strikers: Javier Hernandez, Joshua King, Danny Welbeck, Federico Macheda.