In the other three fixtures in the League Route, Danish side Copenhagen will have to take on Club Brugge, while Turkish giants Fenerbahce meet Romanian side Vaslui. Scottish outfit Motherwell, meanwhile, will meet Panathinaikos.
The first legs of the ties will be played on July 31/August 1, with the return taking place one week later on August 7/8.
The four winners will join Braga, Spartak Moscow, Udinese, Lille, Malaga and Borussia Monchengladbach in the play-offs to decide the five teams progressing from that route to the group stage.
In the champions route, Belgian title winners Anderlecht will go head to head with either Shamrock Rovers of Ekranas, while former European Cup winners Celtic meet either HJK Helsinki or Reykjavik.
|Cluj||v||Slovan Liberec/Shakhter Karagandy|
|Buducnost Podgorica/Slask Wroclaw||v||The New Saints/Helsingsborgs|
|Ulisses/Sheriff||v||Ludogorets Razgrad/Dinamo Zagreb|
|Zilina/Hapoel Kiryat Shmona||v||Neftci PFK/Zestafoni|
The Champions Route clubs are split into two groups, each containing an equal number of seeded and unseeded contenders.
From the 20 sides that will compete in the Champions Route, five will eventually participate in the group stage of the competition following the play-offs.