Martial moved to United from Monaco on the last day of the transfer window, with much fanfare about the size of the transfer fee and the France striker's potential as the next Thierry Henry.
And the 19-year-old echoed Henry, with a slaloming run cutting inside from the left to outwit Liverpool defender Martin Skrtel and net United's third after 86 minutes, following goals from Daley Blind and Ander Herrera.
So with the teenager impressing on his United debut, how did his team-mates react to the performance? Goal takes a look...
Great win for us today. Delighted for @AnthonyMartial on his 1st goal. Hopefully 1st of many for us— Wayne Rooney (@WayneRooney) September 12, 2015