Jack Wilshere also returns for the Gunners while Kyle Naughton replaces Steven Caulker for Spurs, who start both Jermain Defoe and Emmanuel Adebayor in attack
Jack Wilshere is also back in the starting line-up after seeing out his one match suspension against Fulham last week.
Theo Walcott starts in a front three alongside Lukas Podolski and Olivier Giroud and Gunners' captain Thomas Vermaelen continues at left-back in the absence of Keiran Gibbs.
Lloris is preffered in goal ahead of Brad Friedel and Andre Villas-Boas also starts both Jermain Defoe and Emmanuel Adebayor for the first time in the league this season.
Kyle Naughton comes in for the injured Steven Caulker as a make shift left-back, with Jan Vertonghen reverting to centre-back.
Arsenal starting XI: Szczesny; Sagna, Mertesacker, Koscielny, Vermaelen; Wilshere, Arteta; Walcott, Cazorla, Podolski; Giroud.
Subs: Mannone, Jenkinson, Santos, Coquelin, Ramsey, Oxlade-Chamberlain, Arshavin.
Tottenham starting XI: Lloris; Walker, Gallas, Vertonghen, Naughton; Lennon, Sandro, Huddlestone, Bale; Defoe, Adebayor.
Subs: Friedel, Dawson, Livermore, Townsend, Carroll, Dempsey & Sigurdsson.