The Spanish playmaker has overcome a hamstring problem to line-up once more for the Premier League champions, who face a Spurs team minus midweek hat-trick hero Jermain Defoe
The Spanish midfielder last played for the Premier League champions on October 6 in a 3-0 win over Sunderland but has now overcome a hamstring injury he suffered on international duty to take the field against Andre Villas-Boas' men.
Matija Nastasic retains his place at the heart of the defence while Sergio Aguero and Carlos Tevez are given the nod in attack.
The away side welcome fit-again Sandro into the starting XI but Jermain Defoe, fresh from an opportunistic hat-trick against Maribor in the Europa League on Thursday, is dropped as Villas-Boas reverts to his preferred 4-2-3-1 formation.
Leading the line is former City striker Emmanuel Adebayor, while elsewhere Brad Friedel reclaims the No. 1 jersey and Steven Caulker and William Gallas are partnered in central defence.
Manchester City starting XI: Hart; Zabaleta, Kompany, Nastasic, Clichy; Yaya Toure, Barry; Silva, Tevez, Kolarov; Aguero.
Subs: Pantilimon, Kolo Toure, Sinclair, Garcia, Dzeko, Razak, Maicon.
Tottenham starting XI: Friedel; Walker, Gallas, Caulker, Vertonghen; Sandro, Huddlestone; Lennon, Dempsey, Bale; Adebayor.
Subs: Lloris, Naughton, Dawson, Livermore, Carroll, Sigurdsson, Defoe.