The likes of Jack Robinson, Andre Wisdom and Sebastian Coates all play for the Reds in the FA Cup fourth round meeting while Fabio Borini starts for the first time since October
The Uruguay international, who is set to consider his Anfield future in the summer, has been in inspired form for the Reds in the 2012-13 campaign and has already notched 16 league goals for the club this season.
Suarez will be joined in attack by Daniel Sturridge, with the duo having struck up a potent partnership since the England striker's move from Chelsea earlier in the transfer window.
Rodgers has, meanwhile, named an inexperienced back four with Andre Wisdom, Sebastian Coates and Jack Robinson all handed starts.
Fabio Borini starts his first game for the Reds since fracturing his foot in October while Raheem Sterling is also given the nod on the wing.
Oldham make a couple of changes from the side that lost to Notts County in League One on Tuesday, with Lee Croft and Robbie Simpson selected ahead of Chris Taylor and Chris Sutherland respectively.
Oldham starting XI: Bouzanis; Wabara, Byrne, Mvoto, Grounds; Croft, Wesolowski, M'Changama, Simpson; Baxter, Smith.
Subs: Cisak, Brown, Winchester, Tarkowski, Sutherland, Mellor, Taylor.
Liverpool starting XI: Jones; Wisdom, Coates, Skrtel, Robinson; Borini, Allen, Henderson, Sterling; Sturridge, Suarez.
Subs: Gulacsi, Carragher, Shelvey, Lucas, Downing, Gerrard, Suso.