Defending champions Corinthians will face Bolivian, Colombian and Mexican opposition in the next edition of South America's top club competition, which kicks off in January
Meanwhile, 2012's beaten finalists, Boca Juniors, have been placed in a tough group alongside Ecuador's Barcelona, Nacional of Uruguay and Mexican side Toluca.
The winners of the first stage listed below will make up the remaining six places in the group stage.
With the Confederations Cup being held in Brazil in June, the Copa Libertadores will have a break after the quarter-final stage, resuming in July.
Game 1 - Tigre (ARG) vs Dep. Anzoategui (VEN)
Game 2 - Gremio (BRA) vs Liga de Quito (ECU)
Game 3 - Deportes Tolima (COL) vs U. Cssar Vallejo (PER)
Game 4 - Olimpia (PAR) vs Defensor Sporting (URU)
Game 5 - Sao Paulo (BRA) vs Bolivar (BOL)
Game 6 - Deportes Iquique (CHI) vs Leon (MEX)
|Barcelona (Ecu)||Sporting Cristal (Per)||Arsenal (Arg)||Velez Sarsfield (Arg)|
|Nacional (Uru)||Libertad (Par)||The Strongest (Bol)||Penarol (Uru)|
|Boca Juniors (Arg)||Palmeiras (Bra)||Atl. Mineiro (Bra)||Emelec (Ecu)|
|Toluca (Mex)||Match 1 winner||Match 5 winner||Match 6 winner|
|Corinthians (Bra)||Indep. Santa Fe (Col)||Real Garcilaso (Per)||Fluminense (Bra)|
|San Jose (Bol)||Cerro Porteno (Par)||Universidad (Chi)||Huachipato (Chi)|
|Millonarios (Col)||Real Garcilaso (Per)||Newell's (Arg)||Caracas (Ven)|
|Xolos de Tijuana (Mex)||Match 3 winner||Match 4 winner||Match 2 winner|