Walter Mazzarri's men started the season with six wins and a draw from their first seven games and although there has been a slight wobble since then they are still third going into this clash.
But for a last-minute goal from Torino, Napoli would have won all six of their home matches so far in the league.
Napoli are 4/5 (1.80) favourites with Paddy Power to pick up three points on Saturday.
Massimiliano Allegri needs a win desperately and it’s rare that you’ll get a price of 7/2 (4.50) for Milan to win a league game. The draw is available at 5/2 (3.50).
But with the Rossoneri not having won on their travels since their first away game of the campaign, the best bet is to back a Napoli triumph here.
In the other markets, Giampaolo Pazzini, who scored a hat-trick in that solitary away win and has also netted in the last two is available at 6/1 (7.00) with Paddy Power to score first in this one.
Edinson Cavani is the favourite to find the opening goal at 13/5 (3.60).
But Marek Hamsik might be the most tempting of the goalscorer bets – he’s at 17/10 (2.70) to score at any time and has netted in five of Napoli’s 12 league games this season.
In the other markets, over 2.5 goals looks a distinct possibility given that it has paid out in four of six Napoli home matches and four of five Milan away games – that’s at 5/6 (1.83) with Paddy Power.
There's also Napoli to score first, which has happened happened in every game at San Paolo, while Milan haven’t scored in the first half away from home since that first game, an 8/13 (1.62) shot.
But with an odds-on best bet, it's best to go for something a bit more outrageous as the value option.
This is a desperate Milan vintage and with most bookies going 50s for the following scoreline, why not take a punt on Napoli to win 5-1 at a whopping 100/1 (101.00) with Paddy Power.
|Napoli to win at 4/5 (1.80) with Paddy Power
||Napoli to win 5-1 at 100/1 (101.00) with Paddy Power|
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Adam Bate is a professional freelance journalist who specialises in football and betting. He is editor of GhostGoal which can be found here - you can also follow Adam on