A draw in Tashkent would be good enough for the Koreans to go through the knockout stage but Hwang Sun-Hong says they'll be chasing three points and top spot in the group
The K-League outfit sit second in Group E on nine points, behind leaders Adelaide United on 10 points, while the Uzbek club can still progress as they are third on seven points.
However, Hwang, who won the 1997 and 1998 Asian titles with Pohang as a player, said his side would go out for the win in Tashkent with top spot in the the group, and a home Round of 16 game, still a possibility.
"We won't play for a draw because we can still finish top of the group if the other result is favourable for us," Hwang told reporters.
He added: "It is an important match for both teams. Our goal is to reach the quarter-finals, but Bunyodkor are a strong side.
"The first goal will be very important for both teams. In my opinion, whoever scores first will win. We can draw the game."
Bunyodkor boss Mirjalol Qosimov said, like Pohang, his side were looking for the win, although they may employ different tactics in their bid to do so.
"We will look to attack while Pohang will defend and most likely play on the counterattack, so we must take our chances," Qosimov said.
He added: "Both teams have the same goal. I said before the tournament that our group was very strong. We know that we need to win as a draw will allow Pohang to qualify, so we will try and please our fans."