The capital club are no longer in the race for the title and must consider whether to rest European Golden Shoe-chasing Cristiano Ronaldo before next weekend's showdown
A run of three games without victory has ended any hopes Real had of winning La Liga, so their meeting with Javier Aguirre's side represents little more than an undercard clash ahead of the title-deciding bout between their arch-rivals Barcelona and Atletico Madrid, which kicks off two hours later.
Carlo Ancelotti's men have taken just two points from their last three league fixtures, meaning they have gone more than two Liga games without winning for the first time since May 2009.
Real's poor run of domestic form has followed their stunning 4-0 Champions League semi-final second-leg demolition of Bayern Munich.
And it is safe to say Ancelotti will now have more than one eye on next Saturday's Champions League showpiece with neighbours Atletico, when Real go in search of their long-awaited 10th European crown.
However, the Fifa Ballon d'Or winner - who has scored 50 goals in all competitions this season - is sure to be keen to play, as he requires just one more strike to overtake Liverpool's Luis Suarez in the race for the European Golden Shoe.
Other injury concerns for Ancelotti include Angel di Maria (groin), Pepe (calf) and Raphael Varane (knee), although playmaker Xabi Alonso will likely play as he is banned for the Champions League final.
Despite the fact Real may field something of a second string at the Bernabeu this weekend, they should still have too much for a mid-table Espanyol outfit who have nothing to play for.
Aguirre's team have won just one of their last 10 Liga fixtures - a 2-1 victory at Malaga on March 25 - and appear to already be focused on their end-of-season holidays.
Furthermore, Espanyol have not won at Santiago Bernabeu since April 1996, and have been beaten 1-0 by Real on three occasions already this season - once in La Liga, and twice in the clubs' Copa del Rey quarter-final meetings.