The Premier League holders were defeated 4-1 by Manchester City in their last league outing, and, with Robin van Persie a doubt, the pressure is growing on manager David Moyes
The Premier League champions have made a stuttering start to their league campaign, winning just two of their first five matches to slip to eighth.
That has seen pressure heaped on new manager David Moyes already, with the criticism gathering pace following the 4-1 drubbing at the hands of rivals Manchester City last Sunday.
However, United quickly recovered against Liverpool as Chicharito's close-range strike helped them to victory, and Moyes will be hoping to use that momentum to see off West Brom.
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"(Wednesday) was a big game for us. We had lost at Anfield a few weeks ago (1-0 in the Premier League) and at the Etihad on Sunday, and we wanted to put that right."
Hernandez could start again for United against West Brom, given the injury uncertainty hanging over Dutch striker Robin van Persie (groin).
Van Persie - who was the leading scorer in the Premier League with 26 goals last term - has missed the club's last two matches and is a doubt for Saturday's clash.
Midfielder Tom Cleverley also missed Wednesday's win over Liverpool with a knock while Darren Fletcher (illness) is indefinitely sidelined.
After finishing eighth last season, West Brom have started slowly this term, and Steve Clarke's men were dumped out of the Capital One Cup on penalties against Arsenal on Wednesday.
They notched their first Premier League win last week at the fifth attempt as goals from Stephane Sessegnon, Liam Ridgewell and Morgan Amalfitano helped them to a 3-0 victory over Sunderland.
Striker Matej Vydra (hamstring) and midfielder Chris Brunt (groin) could return for the trip to Old Trafford, but goalkeeper Ben Foster (foot) and Zoltan Gera (knee) are long-term absentees.
West Brom have have won just five of 23 Premier League games in 2013 and will enter the match as underdogs given United's outstanding record against them; the Red Devils have won 15 of the last 18 meetings between the two clubs, with the other three being draws.
West Brom last tasted victory against United in March 1984 when goals from Cyrille Regis and Steve MacKenzie fired them to a 2-0 success.
The last clash between the two sides was highly memorable, as West Brom scored three times in the final 10 minutes to earn an incredible point in the only ever 5-5 draw in Premier League history, which was also Alex Ferguson's last match in charge of United.