The Samurai Blue trailed the Black Stars at the break in Saitama but secured a win thanks to three second-half strikes
Japan came from behind to defeat Ghana 3-1 in their international friendly in Saitama on Tuesday.
Alberto Zaccheroni's men went in a goal down at half-time after Frank Acheampong opened the scoring for the visitors midway through the first period.
However, Japan responded in style after the interval and eased to victory thanks to strikes from Shinji Kagawa, Yasuhito Endo and Keisuke Honda.
Ghana went into the game at the Saitama Stadium 2002 after securing a vital World Cup qualifying win over Zambia last Friday - a result that secured their place in the final play-off round as they look to reach Brazil 2014.
And, even though only three of the side that started the fixture in Kumasi began this game, Kwesi Appiah's side looked full of confidence and went ahead after 24 minutes through Anderlecht striker Acheampong.
Japan, who have already secured their place at next year's World Cup, struggled to assert themselves in the first half, but came out with all guns blazing after the break and deservedly drew level just five minutes after the restart.
Manchester United playmaker Kagawa cut inside from the left wing and hit and hit a low drive past the despairing dive of Razak Brimah from 20 yards.
And it did not take long for Zaccheroni's team to edge ahead, as Endo and Honda exchanged a neat one-two before the Gamba Osaka man curled a shot from the edge of the area that squirmed under Brimah just after the hour.
By this point, the hosts were rampant and Endo and Honda combined again to increase their advantage just four minutes later, the former swinging in a free-kick which the latter headed home from eight yards.
Despite the loss, Ghana boss James Kwesi Appiah voiced his happiness with his side's performance against top-level opponents.
"To build a team it is important to play against top teams as Japan. I was very impressed by the performance of my players, they all did well, but at this level if you lose concentration you do face a big blow, but performance-wise it was a good game us," he told reporters after the game.