A late replacement for the injured Proto in the starting XI, but bar the three goals he conceded, he was not called upon for much else.
The right-back looked to get the better of Olaizan at the start of the night, and got beyond his man on occasions but lacked composure in the final third.
Started the game playing extremely deep as he was forced further and further back by Weiss, yet grew into the match in the second half as he began to attack his opponent.
Had a great chance to give his side the lead early on, but his night went from bad to worse as he was at fault for both of Olympiakos' first two goals. However, he was much-improved from there on.
A coming of age for the 16-year-old, who impressed greatly with his set-piece delivery and passing range. Looks to have a bright future in the game.
Arguably the best player in the first half with his deft movement and imaginative play, but he ran out of steam after the break and was replaced by Acheampong.
Anderlecht's most consistent performer on the night, the American was everywhere, breaking up play before pushing forward and supporting the attack.
Did not inspire confidence with his erratic positioning, which arguably forced Nuytinck into making errors, and was no match for Mitroglou's electric play.
The young winger promised to threaten, but didn't have anything to show for it. Impressed with his quick feet and dribbling ability, but lacked an end product.
Didn't give the Olympiakos defence a minute's rest as he teased the visitors frequently thanks to his shooting, and was unlucky to find the back of the net.
A night to forget for the Serbian striker, who got into the right positions yet fluffed a string of gilt-edged chances - including a tame missed penalty with his side 1-0 down - before giving up in the latter stages.
Made a number of fine saves to deny Anderlecht from gaining anything in the match.
Did not make any obvious errors but settled for an easy night as he did not show much attacking intent and instead played it safe at the back.
Together with Manolas, he formed a strong partnership in the heart of Olympiakos' backline, although the early signs showed that they may have been in for a tough night.
A superb performance from the full-back, who constantly helped his defence with a series of blocks and interceptions.
Played a hugely important role in protecting his backline with a number of key interceptions, while he caught the eye with his attacking tendencies, such as the looping header which lead to Mitroglou's second.
Was lucky not to have been punished for conceding a penalty which could have changed the course of the game. However, he picked himself up quickly and was a vital midfield pivot alongside N'Dinga.
The former Manchester City man was electric at times as he took on N'Sakala with purpose. Did not produce much end product, but nonetheless contributed to the victory with his strong forays forward.
A quiet display from the winger who switched flanks with Weiss early on and suffered from the change as he failed to impress. Replaced by Fuster.
It may have been merely a smash-and-grab, but the hitman was in devastating form as he showed his predatory instincts. Took all of his goals with sublime technique, including a peach of a strike to round off his hat-trick. A deserved match-winner.
A performance which harked back to his heyday. The ex-Barcelona and Sevilla star showcased some fancy flicks and tricks and set up Mitroglou for his first with a well-executed cut-back before being replaced.