The Marseille goalkeeper picked up a neck injury during their win over Guingamp that will keep him off the plane to Brazil, with Stephane Ruffier taking his place
The 29-year-old picked up a neck injury in Marseille's 1-0 win over Guingamp on Saturday and was forced to leave the pitch midway through the first half.
Mandanda underwent further examination on Sunday and Marseille have now announced that the shot-stopper will be out of action for an estimated six weeks.
"Mandanda will have to wear a neck brace for the next three weeks and will need an additional three weeks to recover from his injury," the club said in a statement.
The OM goalkeeper was one of three keepers in Deschamps's provisional squad for this summer's tournament in Brazil, alongside Hugo Lloris and Mickael Landreau.
Mandanda's place in the squad will be taken by Saint-Etienne No.1 Stephane Ruffier.