Despite initially allaying fears of a lay-off, Jack Wilshere has been ruled out for six weeks following a crunching challenge by Daniel Agger in the 1-0 win over Denmark on Wednesday.
And Hodgson, speaking before the true extent of the midfielder's injury was revealed, feels that those not boasting full fitness will not be able to last during the busy tournament schedule - such as Scott Parker during Euro 2012.
"I don't think any player would expect me to show loyalty at a time when they are not 100 per cent fit over someone who is 100% fit and can do a good job," he told reporters.
|7/4||England manager Roy Hodgson is 7/4 with PaddyPower to leave before the final game of Euro 2016|
"I would like to think that the answer to the question is obvious and one hopes one wouldn't do that.
"With the amount of people knocking quite heavily on the door, it would be a bit sad to leave [out] someone who is 100% fit and in fantastic form if someone else wasn't fit and might just recover during the tournament."
In addition, Hodgson maintained that no one player is guaranteed a place on the plane to Brazil despite the Three Lions not again being in action until his 30-man provisional squad is announced on May 13.
"It would be a mistake to start trying to read my mind because I haven't made up my mind," the England boss remarked.
"I hope you're not going to do that because Frank Lampard and Ashley Cole are very much in my mind. He [Lampard] is no more vulnerable than anyone else."