The Euro 2012 finalists will miss both the Juventus midfielder, who has a muscle problem, and Andrea Barzagli as they take on the Copa America holders on Sunday
The defender is being plagued by a tendon problem that recurred in the Confederations Cup semi-final defeat against Spain on Thursday and was replaced at half-time due to his physical problems.
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"Pirlo was coming off a muscular problem and did brilliantly to resist throughout the entire match with Spain," team doctor Enrico Castellacci was quoted as saying on the official FIGC website.
"However, as a precautionary measure and in agreement with the coach, we have decided not to risk him for the next game.
"Barzagli is suffering from a recurring tendon problem that had already affected him recently."
Italy will also be without star striker Mario Balotelli in the third place play-off as the AC Milan attacker was sent home earlier this week due to injury.