The former Germany full-back believes the Arsenal star has taken a lax attitude throughout the World Cup and should be dropped for the remainder of the tournament
The Arsenal playmaker has started all of his side's games so far, scoring the deciding goal in the last-16 win over Algeria, but has been criticised for his performances.
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"If [Low] is bold, he'll say: 'I will not play with only 10 people' and drop Mesut Ozil," he told TZ.
"That would be the next step for world titles and above all a big step for the good of the team. Nine men are torturing themselves for 90 minutes and he's going for a walk.
"That's not what you do at a World Cup."
Breitner also believes that the decision to deploy Philipp Lahm at full-back - with Jerome Boateng taking Per Mertesacker's spot at the heart of defence - was the right one.
"He has seen what millions of fans have also seen - namely that we cannot continue with the defence from the previous games.
"We needed a solution and Philipp is not only world class in midfield, but also in defence. Jogi Low corrected his error of judgement."
Germany set up an enticing semi-final tie with Brazil by beating France in the last eight on Friday.