Vicente Del Bosque will attempt to lead his team to a second consecutive triumph in the competition this summer – in what would be a fourth major title on the bounce.
Despite the tough task on their hands, the Manchester City midfielder, 28, believes Spain are more than ready for the challenge ahead.
“We know the environment that awaits us. Now we have a base here and that's great for us. We are ready,” Silva told Marca.
Spain will play the Netherlands in their Group B opener on June 13, in a repeat of the 2010 World Cup final.
Silva was a fringe player in la Roja’s World Cup winning side of 2010 but hopes he will get the chance to play a bigger part in the team's campaign this summer - starting with Louis van Gaal’s side in Salvador.
"The first game is crucial and if we win it, it’s an important game,” Silva said.
"I feel more comfortable behind the front line. I am very good in that position. I attempt to adapt.
“We have very good strikers and we hope to score a lot of goals.”
Silva has made 80 appearances for his country, scoring 20 times, including one in the Euro 2012 final against Italy.