Barca's win over Malaga earlier in the day was not enough as Madrid succeeded in maintaining the seven-point advantage over their Catalan rivals with only two rounds of the campaign remaining.
So, as Real prepare to party long and hard into the night at the Plaza de Cibeles with their fans, Goal.com has catalogued some of the memorable images of Los Blancos' monumental 2011-12 season.
Off with a bang | Ronaldo and Madrid picked up where they left off last season
A Real shock | Madrid suffered their first of two league defeats with a 1-0 loss to Levante
Hit for six | Madrid smashed Rayo for six and Ronaldo hit another hat-trick
Great escape | Real survived a late controversial penalty call to beat Valencia 3-2
Derby delight | Di Maria scored his first goal in El Derbi Madrileno in a 4-1 rout
Bernabeu heartbreak | Benzema's fastest-ever Clasico goal in December wasn't enough
Classic Cristiano | Ronaldo led Sevilla's hammering as Real responded to Clasico loss
Trouble brewing | Mourinho's future was in doubt in early 2012 after fans turned on him
Back in business | Kaka hit form as he inspired Real to wins over Zaragoza and Espanyol
Outrageous | Ronaldo scored with a cheeky back heel in the 1-0 win over Rayo
Show of solidarity | The men in white sent get-well messages to Abidal and Muamba
Under pressure | Three draws in five games saw Real's lead slashed to just four points
Magnificent Seven | Ron notched seventh Liga hat-trick in a single season v Atletico
Camp Nou silenced | The 2-1 win at Barca took Madrid one step closer to La Liga
Cruising to the title | Higuain led the way by scoring the opening goal in Bilbao
Cue celebrations | The Blancos are ecstatic after a 3-0 win over Athletic clinched La Liga
Party in Madrid | "Without Liga, without Champions League Pep is left Mouted/muted"