As with any tournament, the build-up to Euro 2012 has been blighted by players suffering the usual cruel twists of fate and having to come to terms with missing the competition through injury.
Spain’s all-time top goalscorer David Villa missed the final six months of the season for Barcelona after breaking his leg in his side’s Club World Cup game against Al-Sadd.
How will Spain figure without the top marksman? Since making his debut in 2005 Villa has scored 51 goals in 82 appearances for La Roja, an incredible record of better than a goal every other game.
How can a side not miss that kind of record? And that wasn’t the end of the bad news for boss Vincete del Bosque.
A bigger blow to the Spaniards maybe the loss of captain Carles Puyol. The Barcelona defender was ruled out of the tournament after undergoing much-needed knee surgery, leaving Del Bosque short of experience options at the back.
Beyond the back four of Gerard Pique, Raul Albiol, Sergio Ramos and Alvaro Arbeloa no other defender in the Spain squad has other 10 caps. So could Puyol’s loss be crucial?
Moving further north, France are looking build their reputation up once again on the international stage after a disastrous World Cup campaign in 2010.
However, they’ll have to do that without experienced full-backs Eric Abidal and Bacary Sagna.
Abidal retired from the game in May after having to undergo a liver transplant due to a cancer diagnosis in 2011.
Sagna has struggled with injuries all season after breaking his leg last November, and a reoccurrence in early May dashed his hopes of a trip to Poland and Ukraine.
The French have called upon inexperienced players such as Mathieu Debuchy and Gael Clichy as cover, and with the erratic form of Patrice Evra, it could spell trouble for Les Bleus.
Croatia have learned that they will have to do without the services of Ivica Olic as the Bayern Munich striker will not recover from a thigh injury in time for the tournament. With coach Slaven Bilic having lost one of his most influential attacking pieces, can they still make it out of a tough group with Spain and Italy?
Chelsea-bound Marko Marin has had a hard time to confirm his billing as 'Germany's Lionel Messi', and after a season in which he featured infrequently for Werder Bremen, he was omitted from Joachim Low's 23-man party.
Jack Wilshere missed the entirety of the 2011-12 season with a string of injury problems and is just one name on a long list that England boss Roy Hodgson has had to deal with.
Kyle Walker’s damaged toe ruled the first-choice right-back out of action last month, before Frank Lampard, Gareth Barry and Gary Cahill have all succumbed to injury during their two warm-up games.
One cannot simply talk about the England national team without mentioning Frank Lampard, so the Chelsea playmaker's absence at the Euros because of a thigh problem creates a huge gap that Jordan Henderson may not be able to fill.
Rio Ferdinand finally seemed to put his injury problems behind him this season, but he still did not make Roy Hodgson's squad for the Euros reputedly because of his conflict with John Terry. But with Gary Cahill set to miss the tournament, will the Three Lions miss the Manchester United defender?
Finally, Giuseppe Rossi has been incredibly unlucky with injuries of late, managing just nine appearances for Villarreal before being ruled out for nine month with cruciate ligament damange.
However, with the highly-prolific Antonio Di Natale expected to lead the line, and Antonio Cassano and Mario Balotelli as very capable back-ups, the loss can not be classed as severe as others.
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