The Serie A team sailed through with a 5-0 aggregate win, after a comfortable 3-0 second-leg victory over Cluj on Thursday.
A brace from Fredy Guarin and a late goal from Marco Benassi was enough to secure the victory over the Romanian side.
And Stramaccioni, talking to reporters after the game, said he was now looking forward to facing Spurs.
"They're a top side, at Champions League level, but we're Inter and we'll show what we're about," he said.
The Inter boss added that he was pleased with his side’s Europa League performance on the back of a 4-1 defeat to Fiorentina.
“My team gave an excellent response by winning again on the road - something we'd not done in a while - and winning well.
"[Will it have a] positive impact? Let's say today we were angry and smarting after the defeat against Fiorentina. We knew that wasn't the real us in Florence.”