Ba is expected to leave St James' Park because of a £7.5 million release clause in his current deal at the club.
Cisse is disappointed by the news, even though it may mean he can move back to his preferred central striking position in Alan Pardew's side.
He told The Sun: “I adapted well to playing with Demba Ba when I signed last season and he is a vital player for Newcastle.
“I hear the decisions from the directors at the club but, personally, I don’t think this is good news for us.”
Cisse arrived on Tyneside from Bundesliga side Freiburg for £10 million last January and immediately hit the ground running with 13 goals in his first 14 matches.
However, the Senegal international has only managed three in 17 this season after being shifted out to the right flank.
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“I am a Newcastle player and accept the orders of the coach. I am more of a forward but if my work helps it is normal to play in any position I am asked," he continued.
“Any goal at Old Trafford is good but I would have preferred to win the match and not score. We deserved more and are not happy.
“I certainly remember all last season’s goals and I am looking to obtain a similar number. This is my objective — but it’s not easy. I have never demanded an explanation from Alan Pardew.
“I have generated controversies with coaches during my career but Pardew has spoken with me and told me how much confidence he has in my work.
“This season Newcastle are not creating so many goals. But the squad can fight for a much better position in the table.
“Our challenge is still to fight for a European place as opposed to fighting to avoid relegation.
“I am content here in the Premier League. I always dreamed of this experience."
Newcastle visit north London on Saturday to take on Arsenal.