The Dutchman misses out entirely for the reigning Premier League champions whilst the Japan international will be on the pitch from the off for just the third time this term
Boss David Moyes has made four total changes to the side that drew 1-1 with Southampton at the weekend, with Ryan Giggs also stepping in for Marouane Fellaini in the holding midfield pair alongside Michael Carrick, and Antonio Valencia also getting the start in support of Javier Hernandez.
Rafael, Phil Jones, Jonny Evans, and Patrice Evra all maintain their places in the Red Devils' line-up to form the back four, with David De Gea taking up his usual mantle in goal.
Real Sociedad will counter with the attacking trio of Carlos Vela, Haris Seferovic, and Antonie Griezmann as the Spaniards look to claim their first points of the Champions League campaign.
Manchester United starting XI: De Gea; Rafael, Jones, Evans, Evra; Carrick, Giggs; Valencia, Rooney, Kagawa; Chicharito.
Subs: Lindegaard, Smalling, Buttner, Nani, Young, Fellaini, Januzaj.
Real Sociedad starting XI: Bravo, C.Martínez, Mikel, Iñigo, De la Bella; M.Bergara, Zurutuza, X.Prieto; Vela, Seferovic, Griezmann.
Subs: Zubikarai, Ansotegi, Cadamuro, R.Pardo, Ros, Chory Castro, Agirretxe.