The Premier League champions have just two points with four games played and will need to beat Los Blancos and Borussia Dortmund in their final two matches to keep their slim qualification hopes alive.
But Mourinho believes that Roberto Mancini's side will struggle to get through even should they get those results, a situation which he insists is unusual.
"I don't think it's normal when you're out of the competition at a very early stage," he told reporters.
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"Last season City were out in the group phase. I think this season they will be out again. I think they can win on Wednesday, of course, and I think they can win in Dortmund, but eight points is not enough. I think they're out for the second consecutive time, so that must be difficult for them."
The Portuguese, who enjoyed a trophy-laden spell with Chelsea between 2004 and 2007, went on to express excitement over returning to the UK.
"I was looking forward to coming back to England," he added. "I never hide my feelings, even when it means sadness for many people. I admire England, there are tough opponents, but I enjoy the games and the atmosphere.
"I always said how much I loved my time here and I always like to be back. I know when you play in England you have difficult matches, difficult opponents, difficult atmospheres, because the crowd is always very strong behind the team, but I like that.
"I enjoy that and I think also my players are happy to play in England."