The Belgian title holders return to the cream of European club football following a six-year hiatus, and coincidentally faced their forthcoming opponents in their last group-stage appearance, but lost on both occasions.
However, according to their newest recruit from NEC, the Brussels giants have enough quality in their ranks to spring a surprise against the perennial heavyweights, weakened by a mix of high-profile departures and injuries.
"There are opportunities for us," the Netherlands Under-21 defender told Sporza. "With our ability, we can make life very difficult for Milan.
|PURPLE HAZE FOR MILAN|
|16/1||Anderlecht are 16/1 with Bet365 to snatch a 1-0 win at the San Siro|
"How will we go about [picking up a result]? That we'll have to discuss, but I think we have to play our own game. We have enough quality."
The action at San Siro gets under way at 20:45CET.