The Spanish representatives have been paired with Greek opposition, while the Serie A side will have to deal with the Portuguese team, en route to the competition's group stage
In the other four fixtures via the league route, Borussia Monchengladbach take on Dynamo Kiev, while Malaga face Panathinaikos.
Furthermore, Russian giants Spartak Moscow will have to deal with Fenerbahce and 2010-11 Ligue 1 champions Lille await a tie versus Copenhagen.
In the champions route, SPL winners Celtic will face Swedish side Helsingborgs, while Belgian powerhouse Anderlecht meet Cypriot titleholders AEL Limassol.
|BATE Borisov||v||Hapoel Kiryat Shmona|
The first legs of the ties will be played on August 21-22, with the return taking place one week later on August 28-29.