The Argentine coach insists the home side remain firm favourites for the league derby this weekend despite the Rojiblancos' immaculate start to the season
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|7/2||Atleti are 7/2 with Bet365 to beat Real Madrid on Saturday
Simeone's men currently sit joint top in the Primera Division table, holding a two-point lead over los Blancos following their 100 per cent record thus far this season.
However, the Argentine coach insists his charges remain the underdogs and that Atleti's victory over Madrid in last term's Copa del Rey final will count for nothing this weekend.
"Real Madrid are better than us and have a fantastic squad, so we'll have to give 110 per cent," Simeone said at a press conference.
"Real Madrid have top players who can pop up to make the difference at any given moment, which is very difficult to prepare for. I expect Real Madrid to have the ball.
"Last season's Copa del Rey win counts for nothing on Saturday. We go into the game with a lot of hard work under our belt and raring to do well. I don't anticipate it being the same sort of match as last time."
Saturday's encounter is scheduled to kick off at 21:00BST.