The talented attacker joined the Blancos an estimated £30 million, with the Santiago Bernabeu side beating the likes of Manchester City to the signature of the ex-Malaga starlet.
Isco, 21, was left out of the Roja squad for the Confederations Cup in June, but Del Bosque insists that he has a definite future at the centre of the national side.
|9/2||Spain are 9/2 with William Hill to win the World Cup
Another up-and-coming Spanish starlet, Real Sociedad midfielder Asier Illarramendi, has reportedly caught the eye of Real Madrid and the ex-Bernabeu boss added that he could fit into any side he wanted to.
"Illarramendi is the complete midfielder. He has the personality to play for any team in the world," Del Bosque added.
Spain's Confederations Cup ended on a sour note as they were thrashed 3-0 in the final by hosts Brazil and the likes of Alvaro Arbeloa and Iker Casillas came in for criticism for their role in the loss, which displeased Del Bosque who defended his players.
"Alvaro played very well throughout the tournament," he said. "It's as if we are always looking for the weak link, and we are all guilty of that. Casillas was magnificent.
"We played good football at times but the final wiped away everything we did up until then. We now have another year to try to make sure we have a good World Cup - if we qualify."