The Red Devils, who sit 11 points adrift of fourth place in the Premier League, lost 2-0 in Athens and managed just one shot on target, while the Dutch frontman blazed over his only chance of the match.
And now Van Persie, who has already criticised his team-mates after the Champions League last-16 tie, has hit out at the club's “lousy” form and showed little sign of optimism that the Red Devils could arrest their current slump.
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“We are very disappointed. It’s a tough season.”
Van Persie has scored 14 goals in 22 matches for United this season, with his campaign disturbed by injuries, and recently admitted that his team-mates are making it “difficult” for him, forcing the Dutchman to adapt his game.
“Sometimes I try to find ways to do more but in the areas I wanted to play, my team-mates were often there. This makes it difficult for me,” Van Persie told NOS.
“Then I have to change my tactics to suit my team-mates, and play outside my zone. It's a pity.
“We played too slow and could therefore create little.
“I rushed that shot. That's a shame because I don't get a lot of chances so when you get one, you have to score.”