It will be the first time that the two clubs have met in the top division of English football, with their last encounter coming in the Championship in February 2011.
Unlike many of his team-mates, Rangel, who joined Swansea in 2007, has played in numerous matches against their fierce rivals previously but he expects the latest clash to be the most heated.
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"There is extra spice in it and it's going to be really exciting - probably the biggest ever - and the most important thing is to win it."
Rangel warned his team-mates that they must keep a cool head during the match and not let the intensity of the occasion get to them.
"It's a derby and the most important thing is to stick together and enjoy it," he added. "Going to Cardiff is always difficult, we know that, but I don't think it's one you need any motivation for. We know exactly what it means to the fans and to the city.
"We have to play football and try to win it."