The Frenchman, on loan from Marseille, was withdrawn in the first half of the Baggies' 4-1 defeat to Liverpool, and the club are yet to determine the seriousness of the problem
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The Marseille loanee was unable to make it to half-time, replaced by James Morrison in the 44th minute, and Clarke has revealed that the club have yet to diagnose the seriousness of the injury.
"I'm not sure," said Clarke when asked about Amalfitano's condition. "I've not really had a chat with the doctor.
"He was indicating that he had an injury. We tried to get him to half-time but he said it was too bad, so we made the change.
"We'll assess him and see what the problem is."
Amalfitano has scored twice in seven appearances for West Brom this season, his efforts coming in wins over Sunderland and Manchester United.