The Swans' top goalscorer, after spurning a good chance to open the scoring, came off in the second half due to a hamstring concern as both sides failed to break the deadlock.
Laudrup admitted he was not aware of the true extent of the damage and was just as concerned with his side's failed first-half penalty appeal after Matija Nastasic appeared to impede the striker.
"[Michu] has a hamstring problem. I am not sure if he has torn it but, even if it is less than that, this will be his last game of the season," Laudrup told reporters.
"I thought from the bench it was a penalty, and after seeing it again I think even more so. We have had 35 games in the league with no penalties, maybe we will get one next year."
The Swansea boss was, however, content with the point gained and praised his squad for holding last year's Premier League champions at bay.
"I have to be pleased with a point, especially if you analyse the game. In the first 35 minutes we played some very good football and created chances," he continued.
"But if you don't score in your good moments there is always a danger the other team will come into the game, especially a side like Manchester City, who can punish you.
"They had two good chances at the end of the first half, and had a huge chance through Dzeko at the end of the game, so in the end I am pleased with a point against the champions from last season."