The Red Devils will face Kitchee FC on July 29 at the Hong Kong stadium in what will be their first match in the region since 2005.
Following the announcement, Manchester United chief executive David Gill told the club's official website: "The Club has tremendous support throughout China and especially in Hong Kong.
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"We have visited on a number of occasions and after an eight-year gap it’s a pleasure for the team to be able to return to Hong Kong again this year.
"We are looking forward to engaging with our loyal fans, our commercial partners and most importantly preparing for the season ahead."
Meanwhile, Ken K. Ng, chairman of the Kitchee Foundation, also expressed delight at the prospect of welcoming United back to China.
He said: "Kitchee welcomes Manchester United to return to Hong Kong after an absence of eight years. This is indeed a mega event for Hong Kong because Manchester United is undoubtedly the best-supported football club here and their local fan base is legendary."