Trailing Sir Alex Ferguson's men by five points with 15 games remaining, City will once again need a strong finish to win the title, as they did last term, winning each of their last six matches.
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The Argentine's dramatic late goal against QPR on the final day of 2011-12 sealed a remarkable triumph at the Red Devils' expense and he is keen to repeat the feat this time around.
"We won the title off them last season and now we're in the fight again," Aguero declared to The Sun.
"We can regain the leadership of the Premier League from them. City have everything to continue to grow and the best is yet to come.
"I feel the ambition of my team-mates in the dressing room, in training and in the matches.
"I hope that the title we won last season was just the first step."
Roberto Mancini's men trail United by five points after 23 games of the Premier League season. The cross-city rivals are due to meet at Old Trafford on April 6.