With full-backs Jose Enrique and Martin Kelly both out injured, Glen Johnson looks set to carry on at left-back with Wisdom possibly filling in on the right side.
But should manager Brendan Rodgers pick him, the young defender is confident he will be able to handle the pressure of the game.
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"I'm not a nervous person. I just take things in my stride and try to keep my head down and get on with stuff. You can't allow the pressure to get to you.
"United have some great players but so do we and our form has been good. We'll go there with the right attitude and give it our all.
"We'll have a strong team out and confidence is high. We know how much this game means to the fans. The support they give us is unbelievable and hopefully we can reward them with a good result."
If the 19-year-old steps out at Old Trafford on Sunday, it would cap a memorable week for the defender who recently signed a new long-term contract at the club.