La Roja have not beaten their South American opponents in their last 11 attempts and are up against it at 9/2 (5.50) with Coral to come out on top at the Rogers Centre.
In fact, Luiz Felipe Scolari's men have won eight of the last nine encounters between the sides and are clear 4/7 (1.57) favourites to record another victory on Tuesday.
That eight-match winning streak was brought to an end by a 2-2 draw in the last meeting back in April, and you can get odds of 3/1 (4.00) on the teams sharing the spoils once again.
Such a high-profile clash between two top-class international sides is sure to attract a sellout Canadian crowd, with goalmouth action all but guaranteed considering the attacking talent on display.
Both teams have 27 goals to their name in their last 10 respective fixtures and the fans are unlikely to have to wait long to see the net ripple when they go head-to-head.
Jorge Sampaoli's men silenced the crowd with an opening goal after just seven minutes at Wembley, the eighth time in 10 games that they have hit the net within 20 minutes, while their opponents have struck in the first 25 in three if their last five games.
Two goals had already been scored by the 28th minute when the teams last met in April, so odds of 5/6 (1.83) look like a safe bet on at least one going in by that time tonight.
Although Brazilian superstar Neymar may be the most high-profile player on display in Toronto, his Barcelona team-mate Alexis Sanchez is the man on form at the moment.
Having scored both goals in the win over England, the Chilean forward has now hit 10 goals in his last 10 games for club and country, and offers tempting value at 11/4 (3.75) to strike anytime here.
|Goal within 1st 28 minutes for a 1.5pt stake at 5/6 (1.83) with Coral
||Alexis Sanchez to score anytime for a 1pt stake at 11/4 (3.75) with Coral
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Al Hain-Cole is a Liverpool fan, experienced tipster and avid follower of European football. He specialises in accumulators and if you would like to read more from Al you can follow him on Twitter here.