The home side are the clear favourites with Bet365 for victory at 10/11 (1.90), a good price given their recent dominance over Chelsea on their own patch.
The last time the two sides met was a dull 0-0 draw at Stamford Bridge though, and another stalemate can be backed this time around at 13/5 (3.60).
Chelsea are 3/1 (4.0) outsiders to win the game having last tasted success in the blue side of Manchester back in 2008 thanks to goals from Ricardo Carvalho, Frank Lampard and Nicolas Anelka.
While Lampard remains, much has changed since then with City becoming a more powerful domestic force under Roberto Mancini, and his side look unlikely to fall to defeat here given their dominance at home and without a European campaign to factor in.
City are still in with a great shout of FA Cup success, but unlike Chelsea will not have to utilise any energy in midweek European encounters across the continent.
The Blues on the other hand could be drained from their Europa League encounter on Thursday night when they were fortunate to progress thanks to a late strike from Eden Hazard.
One player who is crucial to City's title tilt is Argentina international Sergio Aguero, who now has three goals in as many games.
While Mancini maintains reservations about Carlos Tevez due to their falling out last season, and used Edin Dzeko largely as a super sub earlier in this campaign, Aguero is his most trusted forward.
After a quiet spell of three games without a goal in January, Aguero looks back on form and scored twice against Leeds last weekend.
Another goal here is available at 6/5 (2.20) anytime, but more tempting yet is Aguero to score first at 9/2 (5.50).
|Man City to win at 10/11 (1.90) with Bet365
||Sergio Aguero to score first at 9/2 (5.50) with Bet365
Jamie Dickenson is a 22-year-old freelance journalist who specialises in football, sports and betting.
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