A win would move Vladimir Petkovic's side to within four points of second-placed Napoli, but that is easier said than done at a ground where they have not won since 2006.
Two points from their last five visits to the Artemio Franchi is a disappointing return for the Biancocelesti, but they are still favourites at 6/4 (2.50) with Bet Victor to break that hoodoo and secure a vital victory in this match.
Giuseppe Iachini's men have won their last two home games, and are available at 11/5 (3.20) to make it three in a row.
The visitors have drawn three of their last five away games in Serie A, and you can get odds of 11/5 (3.20) on them having to settle for a point once again.
The men from the capital seem to have lost their defensive resolve in recent weeks, and have now failed to keep a clean sheet in seven matches in all competitions.
Luckily for the backline, their attacking counterparts have generally been fulfilling their side of the bargain a little more reliably, having hit the back of the net in all but one of those seven fixtures.
Considering both teams have also scored in eight of the hosts' last 11 outings, it seems safe to back goals at each end tonight, particularly with generous 9/10 (1.90) odds on offer from Bet Victor.
After suffering six consecutive league defeats over December and January, Siena have now lost just one of their last four games, and it is surely no coincidence that this upturn in fortunes has coincided with the introduction of Innocent Emeghara to the starting line-up.
The January loan signing from Lorient has already added an extra dimension to one of the league's poorest attacks, having opened the scoring on his full debut against Inter and then making it two in two with the first goal at Bologna.
With form like this behind him, the Switzerland international looks like great value at 15/2 (8.50) to score first once again in this game. The 12/5 (3.40) price for him to score anytime with Bet Victor could also be of interest to those looking for a solid bet at odds-against.
|Both teams to score at 9/10 (1.90) with Bet Victor
||Innocent Emeghara to score first at 15/2 (8.50) with Bet Victor
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Al Hain-Cole is a Liverpool fan, experienced tipster and avid follower of European football. He specialises in accumulators and if you would like to read more from Al you can follow him on Twitter here.