Bayern Munich trio Bastian Schweinsteiger, Toni Kroos and Jerome Boateng and Borussia Dortmund's Marcel Schmelzer are set to miss Germany's encounter against the Netherlands next week due to injuries.
Die Roten have announced that both the experienced midfielder and the young playmaker are suffering from infections, which will keep them from taking part in the friendly match in Amsterdam.
Elsewhere, the German FA (DFB)'s official website has confirmed that Boateng picked up a hamstring injury against Eintracht Frankfurt on Saturday, while Schmelzer has a bruised ankle.
Meanwhile, Schalke defensive midfielder Roman Neustadter has expressed his delight at being called up by national team coach Joachim Low for the first time.
"At first I was shocked, because I didn't expect it," the 24-year-old explained to Bundesliga.de. "Of course I was extremely delighted and could not find words for the joy I felt.
"[Low] said that I deserve it due to my performance, he now would like to get to know me and that he is looking forward to Monday."
Germany and Netherlands face off in Amsterdam