Les Bleus have a great record in major tournaments against Vicente Del Bosque's side, but can the reigning champions take another step towards defending their crown?
With enhanced prices specials as well as some good value longshot bets, we analyse where you should consider putting your money ahead of one of the most eagerly anticipated clashes of the quarter-finals.
||Andres Iniesta to score and Spain to win
|William Hill have enhanced two wincast bets ahead of this clash - the first of which is a 5/1 quote on Andres Iniesta to score at any time in 90 minutes and Spain to win the match in normal time. The Barcelona midfielder scored the goal that won his side the World Cup in 2010 and this quote is sure to be a popular pick.
||Karim Benzema to score anytime and France to win
|The second offer concerns Karim Benzema. The Real Madrid striker has had a good domestic season but has yet to find the net at the European Championships. William Hill offer 8/1 that Benzema scores at any time in a France win.
||Spain to win to nil
|Spain have beaten France without conceding in the last two meetings between the sides, and have also won two of their three games at this tournament without conceding; another win to nil in this game is priced at 8/5 by William Hill.
||Jesus Navas to score last
|Jesus Navas scored the winning goal against Croatia in Spain's last group game, and the Sevilla forward is priced at 14/1 to score the last goal in this game.
||Yohan Cabaye to score anytime 7/1
|Yohan Cabaye has looked dangerous for France in the tournament so far, scoring once and creating opportunities when breaking from midfield. The 26-year-old is 7/1 to score at any time with William Hill.