The Protectors coach has encouraged his team to do their best and reminded them to not be complacent against the Myanmar National League champions
Despite having some concerns about the team's overall fitness, the Protectors head tactician Lee Lim-Saeng remained optimistic his squad will bounce back after their loss at Chonburi in the last match.
"We are confident that we can beat them and we want a win because our ambition is not just to qualify for the next round, but to finish in first place and to have a home game in the next round," he told reporters.
"But we have had problems with injuries and we were only able to bring 15 players with us as a result of that."
He added: "Yangon United may be last in this group but we are not looking down on them although we will be trying our best to get a win."
On the other hand, Yangon United boss Eric Williams ensured that his team will provide significant counterwork against the Singapore outfit.
"I think that this match is very important for our team," he said. "We only have one point so far and we will have to try very hard to get a win because if we don't beat Home United, we won't have much of a chance to qualify for the next round.
"It's do or die for us. We must get the goals to beat them and get the three points."
Previously, Home United suffered an away 1-0 defeat to Thai Premier League runners-up Chonburi, while Yangon United also lost 2-1 against Citizen in the Hong Kong trip.