The Uruguayan struck inside the first minute to hand his side another victory which sees them confirmed as qualifiers from the groupEdinson Cavani was once again the difference for Paris Saint-Germain against APOEL as his first-minute goal secure a 1-0 win.
The Ligue 1 champions were missing striker Zlatan Ibrahimovic because of a heel injury, but still had too much for their Cypriot opponents at the Parc des Princes.
This was underlined as early as the first minute when Edinson Cavani collected a Gregory van der Wiel cross in the box before firing in a shot on the turn.
Cavani also planted a header against the base of the post as the home side wasted a host of good chances, but, in the end, one goal was all they required.
The win extends PSG's unbeaten record in all competitions this season and takes them to 10 points from their four Champions League matches in Group F – a total that can only be overtaken by second-placed Barcelona, who beat Ajax 2-0 on Wednesday and host Laurent Blanc's men in the final round of group games on 10 December.
In contrast, APOEL are still seeking a first away victory in the Champions League proper, with this their fifth defeat in 10 matches.
This second successive loss to PSG leaves them bottom of the group with just a single point to their name and braced for a battle with Dutch side Ajax for a consolation place in this season's Europa League.
The Cypriot side faced a major uphill battle from the moment goalkeeper Urko Pardo allowed Cavani's shot on the turn to beat him and find the corner of the net after just 54 seconds.
That said, APOEL should have been level 10 minutes later when Nuno Morais somehow contrived to fire over from point-blank range after Salvatore Sirigu had pushed out an initial header from a corner.
From then on it was largely one-way traffic, albeit with no end product.
A mixture of the woodwork, Pardo and PSG's profligacy prevented the scoreline being bigger at the break.
Cavani hit the post with a diving header inside the box – which Ezequiel Lavezzi and Javier Pastore made a mess of following up – before the keeper produced a superb save to tip Lucas' goal-bound shot just past the upright.
In the second half, Pardo was alert again to block a chipped effort from Pastore from an angle and Cavani curled a brace of efforts wide of the post as PSG tried for a game-killing second goal that was ultimately unnecessary.