The hosts may be in the relegation zone but are unbeaten in their last 11 league games at Estadio Jose Zorrilla, meaning that Madrid could potentially be in for a tricky test.
Nevertheless, William Hill price them as the clear favorites at 1/6 (1.18) while Valladolid are offered at 14/1 (15.00) and the draw is available at 6/1 (7.00).
Madrid's form away from Santiago Bernabeu has been generally extremely solid this season, with Carlo Ancelotti's men the top scorers in the division on the road.
Their opponents tonight have struggled badly in front of goal, meanwhile, finding the back of the net just three times in their last six games.
The price, therefore, of 11/10 (2.10) for Madrid to win without conceding looks extremely tempting and even more so when considering the regularity with which is has paid out in recent weeks.
This has been the correct selection in four of Madrid's last five league games, with the side from the capital showing fantastic defensive solidity, stifling opponents infinitely more creative and dangerous than Valladolid.
Recently, Madrid have won without conceding against both Borussia Dortmund and Bayern Munich in the Champions League as well as Real Sociedad, Osasuna and Almeria domestically.
Juan Ignacio Martinez's side are one of the lowest scoring outfits in La Liga and that is unlikely to change on Wednesday, so backing an away win with a clean sheet should allow punters to make a healthy profit.
|Real Madrid to win and keep a clean sheet at 11/10 (2.10) 3.0pt stake with William Hill|
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Phil Kitromilides is a sports journalist and TV presenter in Madrid