The 61-year-old also gave his views on the war-of-words between the Barcelona star and Real Madrid's Pepe, and warned his side against becoming complacent
The Barcelona star had been a doubt for La Roja's upcoming World Cup 2014 qualifiers after picking up a knock in last Sunday's El Clasico, but Del Bosque has revealed that the 28-year-old is likely to feature in both matches.
“Iniesta is a specific case, he could play both games perfectly, but we will focus," he told reporters at a press conference.
"We have players on the roster who can replace him, but he will almost certainly play both games.”
The 61-year-old also gave his thoughts on the on-going dispute between Iniesta and Real Madrid defender Pepe, in the aftermath of the 2-2 draw at Camp Nou.
“These players do not know theatre. Here everyone wants to be the purest and cleanest. Anyway, the players are focused on the match against Belarus, that's what's important right now,” he said.
Del Bosque then went on to warn his players against complacency when they take on Belarus on Friday, pointing to Bayern Munich's shock defeat at the hands of BATE Borisov as proof that their opponents should not be taken lightly.
“We are not clear who will win, in sport there is no guarantee,” he added. "Just ask Bayern Munich, who lost in this same stadium.
“We have watched the Belarusian team, mainly the last three games they've played. We've also paid attention to their Under-21 team and to BATE, we put eyes on their game against Bayern.”