Striker Victor Ochieng grabbed a brace while Mike Barasa and creative midfielder Bernard Mang'oli scored a goal each for the comfortable victory and a place in the last four of the domestic Cup.
The match began on a high note with Leopards showing their intent and it did not take long before Mang'oli opened the score sheet beating Karuturi's goal keeper Noah Ayuko in the eighth minute. Mustapha Ogutu leveled the scoreline for the visitors in the 22nd minute.
However Ingwe cheered on by home fans, who had turned up in numbers, continued to play with much conviction and purpose .Speedy winger Paul Were broke into a run from the flanks to release a cross which striker Victor Ochieng headed into the net in the 40th minute leaving Ayuko dejected between the sticks.
Ayuko put up an erratic performance misjudging the cross to enable Ochieng slot home. It was a good day in office for the former Chemelil striker as he added another in the 62nd minute flipping in a Jimmy Bageya cross.
Mike Barasa then completed the rout with a fine finish in the 63rd minute. Leopards will now meet the winner between Gor Mahia and Muhoroni Youth in the semi finals.