Andre Villas-Boas has decided to start Emmanuel Adebayor up front alongside Jermain Defoe before the Togo international joins up with his national squad for the Africa Cup of Nations.
Former Spurs boss Harry Redknapp has made four changes to the side that drew against West Brom in the FA Cup, with Nedum Onuoha, Shaun Derry, Fabio and Shaun Wright-Phliips all coming into the team.
Midfielder Esteban Granero misses out with a hamstring injury for the hosts, who have left Djibril Cisse on the bench in favour of Jamie Mackie up front.
Gareth Bale returns to the Spurs starting line-up after serving his one-match suspension, while the Portuguese coach has restored a number of key players to the side after resting them against Coventry in the FA Cup.
Kieron Dyer has had his contract terminated by QPR, so will not feature in the north London clash, while Ryan Nelsen is playing for the hosts despite agreeing to become Toronto's head coach.
Spurs have a strong bench and will be able to call on the likes of Scott Parker, Clint Dempsey and Benoit Assou-Ekotto to change the game if needed.
QPR: Cesar; Onuoha, Hill, Nelsen, Fabio; Mbia, Park, Derry; Taarabt, Wright-Phillips; Mackie.
Subs: Green, Ferdinand, Cisse, Ben Haim, Faurlin, Bothroyd, Campbell.
Tottenham: Lloris; Walker, Dawson, Vertonghen, Naughton; Lennon, Sandro, Dembele, Bale; Adebayor, Defoe.
Subs: Friedel, Caulker, Assou-Ekotto, Parker, Huddlestone, Sigurdsson, Dempsey.