Brendan Rodgers keeps faith with youth for the visit of the Red Devils, who are without their captain, while David de Gea has been dropped in favour of Anders Lindegaard
Shelvey caught the eye with a two-goal cameo for the Reds in Thursday's Europa League clash against Young Boys, and takes a starting place alongside fellow youngsters Martin Kelly and Raheem Sterling.
United, meanwhile, are without captain Nemanja Vidic, despite the Serb playing the full 90 minutes against Turkish giants Galatasaray on Wednesday.
In his absence, Rio Ferdinand partners Jonny Evans in the heart of the Red Devils' defence, while Anders Lindegaard is preferred to David de Gea in goal and Robin van Persie leads the line.
Liverpool (4-3-3): Reina; Kelly, Skrtel, Agger, Johnson; Allen, Gerrard, Shelvey; Borini, Suarez, Sterling.
Subs: Jones, Enrique, Sahin, Assaidi, Henderson, Carragher, Suso.
Manchester United (4-2-3-1): Lindegaard; Rafael, Evans, Ferdinand, Evra; Carrick, Giggs; Valencia, Kagawa, Nani; Van Persie.
Subs: De Gea, Anderson, Hernandez, Welbeck, Scholes, Cleverley, Buttner.