The home side was too strong for their southern African counterparts in a friendly encounter in the Rainbow Nation
Two goals from striker Bernard Parker were enough to see the 2010 World Cup hosts to a comfortable win over their southern African neighbour.
Bafana Bafana dominated proceedings throughout the 90 minutes, with 18 shots going the way of the home side, while the Mambas managed nine attempts.
South Africa opened the scoring early on with a crisp and calmly placed finish from Kaizer Chiefs' Parker in the seventh minute, receiving a pass and sliding the ball past keeper Nelson Logomale into the back of the net.
The relatively small crowd in Nelspruit were brought to their feet by the early goal, an element that has eluded Bafana in recent times, and confidence was visible throughout the squad for the rest of the match.
The South African defence, marshalled by captain Bongani Khumalo, rose to the occasion and was rarely troubled by a Mozambican outfit that had defeated Morocco 2-0 on the weekend in a 2013 Africa Cup of Nations qualifier. Though it is important to note that some of the players from that victory in Maputo were not included in Wednesday's encounter.
Shortly before half time Bafana fans in the stadium believed that their team had extended their lead, as Siphiwe Tshabalala's free kick found Khumalo, who headed the ball into goal, but the match official controversially disallowed the effort for a foul in the area.
The second half brought with it further dominance for Gordon Igesund's men, in only his second match in charge of the South African national team. Bafana could have done better with the chances they created, but the finishing was not of the quality required to profit from their possession.
As time ticked away in the game, frustration got the better of former Bidvest Wits defender Almiro Lobo, and he received a second yellow card, leading to his sending off on a sour night for Mozambican football.
With a few minutes remaining in the match, Parker ended the game in the same way as it began, with a goal courtesy of fine finishing past the Mambas keeper.
The 2-0 victory will be a great boost for Bafana, and Igesund will be feeling confident that his side possesses the crucial elements needed for success, as he continues his task of moulding them into Afcon material ahead of the showpiece to be hosted in South Africa early next year.