The pair both played in the 2-2 draw with Japan on Friday but will not feature on Tuesday after picking up injuriesNetherlands coach Louis van Gaal has confirmed that both Arjen Robben and Nigel de Jong will miss Tuesday's friendly with Colombia after sustaining ankle injuries.
Both players featured in the Oranje's 2-2 draw with Japan last Friday, with Robben scoring the goal that put Van Gaal's side two goals to the good after 39 minutes.
Milan midfielder De Jong was withdrawn midway through the second half, although the Bayern Munich winger played the full 90 minutes.
"There is still fluid in his (Robben's) ankle," Van Gaal said.
"This game comes too soon, but I think he can play next weekend (when Bayern face Borussia Dortmund).
"De Jong was replaced with an ankle injury. It's nothing serious, but the game with Colombia comes too soon.
"They have now returned to Bayern Munich and Milan."